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The peptide reduces pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6, and inhibits M1 macrophage activation

No completed human clinical trials exist yet, though Phase 1 data for the analog CB4211 showed promising metabolic improvements

doi:10.2174/1570159x13666160502153022 About the Author Scott Froum, DDS Editorial Director Scott Froum, DDS, a graduate of the State University of New York, Stony Brook School of Dental Medicine, is a periodontist in private practice at 1110 2nd Avenue, Suite 305, New York City, New York

The disadvantage is larger injection volumes, which some people find uncomfortable